Blog
MTHFR mutations: methylation, homocysteine, and biological age
MTHFR gene variants affect methylation, raise homocysteine, and may accelerate biological aging. Learn what the science says and how to optimize your methylation cycle.
Nature exposure and biological aging: the forest bathing evidence
Forest bathing (shinrin-yoku) lowers cortisol, boosts NK cell activity, and reduces inflammatory markers. Discover the science of how nature slows biological aging.
Nutrigenomics: how genes determine your optimal diet for longevity
Your genes influence how you respond to food. Learn how nutrigenomics personalizes nutrition for aging, from MTHFR to APOE to caffeine metabolism — and what the science actually supports.
Pharmacogenomics and aging: why the same drug works differently after 50
Drug metabolism declines 30% after 70 and varies by genotype. Learn how pharmacogenomics, CYP450 enzymes, and aging interact to affect medication safety and effectiveness.
Polygenic risk scores: predicting disease risk from DNA
Polygenic risk scores combine thousands of genetic variants to predict disease risk. Learn how PRS works, what it reveals about longevity, and its current limitations.
Purpose and longevity: the science of ikigai
Having a strong sense of purpose reduces mortality risk by up to 46%. Discover the science behind ikigai and how purpose protects against biological aging.
Sarcopenic obesity: when you're losing muscle and gaining fat at the same time
Sarcopenic obesity affects 11% of adults over 60 and raises mortality risk by 83%. Learn why losing muscle while gaining fat accelerates aging and how to reverse it.
Serotonin and aging: why mood regulation gets harder after 40
Serotonin receptors decline 10-15% per decade after 40. Learn why mood regulation gets harder with age and how to protect your serotonin system for longevity.
Alzheimer's prevention: 14 modifiable risk factors that account for 45% of cases
The 2024 Lancet Commission identifies 14 modifiable dementia risk factors. Learn which ones can be changed to help protect long-term brain health.